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AttributesValues
rdf:type
rdfs:label
  • Anthramycin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Organic Chemical
Preferred_Name
  • Anthramycin
UMLS_CUI
  • C0003167
CAS_Registry
  • 4803-27-4
FDA_UNII_Code
  • 0WZD9Y66WN
Contributing_Source
  • FDA
Chemical_Formula
  • C16H17N3O4
Legacy_Concept_Name
  • Anthramycin
FULL_SYN
  • 3-(5,10,11,11a-tetrahydro-9,11-dihydroxy-8-methyl-5-oxo-1h-pyrrolo(2,1-c)(1,4)benzodiazepin-2-yl)-2-propenamideSNNCI
  • AnthramycinPTNCI
  • AnthramycinSYNCITCGA
  • ANTHRAMYCINPTFDA0WZD9Y66WN
DEFINITION
  • A pyrrolo(1,4)benzodiazepine antineoplastic antibiotic isolated from the bacterium Streptomyces refuineus var. thermotolerans. Anthramycin binds covalently to guanine in the minor groove of DNA, thereby inhibiting DNA replication and RNA and protein synthesis. (NCI04)NCI
code
  • C252
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