About: Pegylated Interferon Alfa

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Pegylated Interferon Alfa
rdfs:subClassOf	Recombinant Interferon Alfa
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Pegylated Interferon Alfa
UMLS_CUI	C0907160
Accepted_Therapeutic_Use_For	Hepatitis C.
In_Clinical_Trial_For	See separate agents.
PDQ_Open_Trial_Search_ID	43151
PDQ_Closed_Trial_Search_ID	43151
Legacy_Concept_Name	Pegylated_Interferon_Alfa
FULL_SYN	Pegylated Interferon AlfaPTNCI PEG-interferon alfaSYNCI PEG-IFN-aABNCI
DEFINITION	A covalent conjugate of recombinant interferon alpha and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent. The biological activity of this agent is derived from its interferon alpha protein moiety. Interferons alfa bind to specific cell-surface receptors, leading to the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer, and immune-modulating effects. The PEG moiety lowers the clearance of interferon alpha, thereby extending the duration of its therapeutic effects, but may also reduce interferon-mediated stimulation of an immune response. (NCI04)NCI
code	C2491
is rdfs:subClassOf of	PEGINTERFERON ALFA-2B PEGINTERFERON ALFA-2A
is someValuesFrom of	nodeID://b647704 nodeID://b702222

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