About: Oteracil Potassium     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Oteracil Potassium
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Inorganic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Oteracil Potassium
NSC_Code
  • 28841
UMLS_CUI
  • C0393003
CAS_Registry
  • 2207-75-2
FDA_UNII_Code
  • 4R7FFA00RX
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 42586
PDQ_Closed_Trial_Search_ID
  • 42586
Chemical_Formula
  • C4H2N3O4.K
Legacy_Concept_Name
  • Potassium_Oxonate
FULL_SYN
  • OXOABNCI
  • Oxonic Acid, Potassium SaltSYNCI
  • Oxonate PotassiumSYNCI
  • Potassium OxonateSYNCI
  • Oteracil PotassiumPTNCI
  • OTERACIL POTASSIUMPTFDA4R7FFA00RX
  • Potassium oxonateSYDTPNSC0028841
  • Oxonate, potassiumSYDTPNSC0028841
DEFINITION
  • The potassium salt of oxonate, an enzyme inhibitor that modulates 5- fluorouracil (5-FU) toxicity. Potassium oxonate inhibits orotate phosphoribosyltransferase, which catalyzes the conversion of 5-FU to its active or phosphorylated form, FUMP. Upon oral administration, Oxonate is selectively distributed to the intracellular sites of tissues lining the small intestines, producing localized inhibitory effects within the gastrointestinal tract. As a result, 5-FU associated gastrointestinal toxic effects are reduced and the incidence of diarrhea or mucositis is decreased in 5-FU related therapy.NCI
code
  • C2415
is someValuesFrom of
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