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AttributesValues
rdf:type
rdfs:label
  • Ampicillin
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Organic Chemical
Preferred_Name
  • Ampicillin
NSC_Code
  • 528986
UMLS_CUI
  • C0002680
CAS_Registry
  • 69-53-4
FDA_UNII_Code
  • 7C782967RD
Contributing_Source
  • FDA
Chemical_Formula
  • C16H19N3O4S
Legacy_Concept_Name
  • Ampicillin
CHEBI_ID
  • CHEBI:28971
FULL_SYN
  • (2S,5R,6R)-6-((R)-2-Amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic AcidSNNCI
  • AMPICILLINPTFDA7C782967RD
  • AmpicillinPTNCI
DEFINITION
  • A broad-spectrum, semi-synthetic, beta-lactam penicillin antibiotic with bactericidal activity. Ampicillin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis. Ampicillin is stable against hydrolysis by a variety of beta-lactamases, therefore, can be used in wide range of gram-positive and -negative infections.NCI
code
  • C239
is Has_Free_Acid_Or_Base_Form of
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