About: Liposomal Cytarabine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Liposomal Cytarabine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • Liposomal Cytarabine
NSC_Code
  • 715320
UMLS_CUI
  • C0795597
Accepted_Therapeutic_Use_For
  • Lymphomatous meningitis
In_Clinical_Trial_For
  • Large B-cell Non-Hodgkins lymphoma; neoplastic meningitis
ALT_DEFINITION
  • A form of the anticancer drug cytarabine that is contained inside very tiny, fat-like particles. It may have fewer side effects and work better than cytarabine. It is used to treat lymphoma that has spread to the meninges (three thin layers of tissue that cover and protect the brain and spinal cord). It is also being studied in the treatment of other types of cancer. It is a type of antimetabolite.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42260
PDQ_Closed_Trial_Search_ID
  • 42260
Legacy_Concept_Name
  • Liposomal_Cytarabine
FULL_SYN
  • DepoFoam Encapsulated CytarabineSYNCI
  • Encapsulated CytarabineSYNCI
  • Liposomal cytarabineSYDTPNSC0715320
  • cytarabine liposomePTNCI-GLOSSCDR0000579859
  • liposomal cytarabinePTNCI-GLOSSCDR0000579858
  • DTC 101CNNCI
  • DepoCytBRNCI
  • Depo-CytPTNCI-GLOSSCDR0000579860
  • Cytarabine LiposomeSYNCI
  • DepoCyteFBNCI
  • Liposomal CytarabinePTNCI
DEFINITION
  • A liposomal intrathecal formulation of the antimetabolite cytarabine. As an S-phase-specific antimetabolite, cytarabine is phosphorylated by deoxycytidine kinase to a triphosphate form which competes with thymidine for incorporation into DNA; the incorporation of cytarabine triphosphate into DNA appears to inhibit DNA polymerase and so DNA synthesis, resulting in cell death. (NCI04)NCI
code
  • C2388
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