About: Amiodarone Hydrochloride

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Amiodarone Hydrochloride
rdfs:subClassOf	ANTIARRHYTHMICS Cation Channel Blocker nodeID://b645425
Has_Free_Acid_Or_Base_Form	AMIODARONE
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Amiodarone Hydrochloride
NSC_Code	85442
UMLS_CUI	C0700442
CAS_Registry	19774-82-4
Accepted_Therapeutic_Use_For	Ventricular Fibrillation and Ventricular Tachycardia
FDA_UNII_Code	976728SY6Z
Contributing_Source	FDA
ALT_DEFINITION	A drug used to treat certain types of abnormal heart rhythms that have not gotten better with other drugs. Amiodarone hydrochloride affects the electrical activity of the heart. It is a type of antiarrhythmic agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID	39410
PDQ_Closed_Trial_Search_ID	39410
Chemical_Formula	C25H29I2NO3.ClH
Legacy_Concept_Name	Amiodarone
FULL_SYN	amiodarone hydrochloridePTNCI-GLOSSCDR0000642962 Amiodarone HydrochloridePTNCI AMIODARONE HYDROCHLORIDEPTFDA976728SY6Z CordaroneBRNCI NexteroneBRNCI
DEFINITION	The hydrochloride salt of an iodine-rich benzofuran derivative with antiarrhythmic and vasodilatory activities. As a class III antiarrhythmic agent, amiodarone blocks the myocardial calcium, potassium and sodium channels in cardiac tissue, resulting in prolongation of the cardiac action potential and refractory period. In addition, this agent inhibits alpha- and beta-adrenergic receptors, resulting in a reduction in sympathetic stimulation of the heart, a negative chronotropic effect, and a decrease in myocardial oxygen demands. Amiodarone may cause vasodilation by stimulation of the release of nitric oxide and cyclooxygenase-dependent relaxing endothelial factors.NCI
code	C236
is someValuesFrom of	nodeID://b645427 nodeID://b645430 nodeID://b645433
is Has_Salt_Form of	AMIODARONE

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