About: Cefotaxime Sodium     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Cefotaxime Sodium
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Organic Chemical
Preferred_Name
  • Cefotaxime Sodium
UMLS_CUI
  • C0700445
CAS_Registry
  • 64485-93-4
FDA_UNII_Code
  • 258J72S7TZ
Contributing_Source
  • FDA
Chemical_Formula
  • C16H16N5O7S2.Na
Legacy_Concept_Name
  • Cefotaxime_Sodium
CHEBI_ID
  • CHEBI:3498
FULL_SYN
  • Cefotaxime SodiumPTNCI
  • CEFOTAXIME SODIUMPTFDA258J72S7TZ
  • ClaforanBRNCI
DEFINITION
  • The sodium salt form of cefotaxime, a beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Cefotaxime sodium binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linking of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to the second and first generation cephalosporins, cefotaxime sodium is more active against gram-negative bacteria and less active against gram-positive bacteria.NCI
code
  • C2328
is Has_Salt_Form of
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