About: Glutaminase-Asparaginase     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Glutaminase-Asparaginase
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Enzyme
Preferred_Name
  • Glutaminase-Asparaginase
NSC_Code
  • 215140
NCI_META_CUI
  • CL414515
CAS_Registry
  • 39335-03-0
In_Clinical_Trial_For
  • intraperitoneal metastatic tumors.
PDQ_Open_Trial_Search_ID
  • 39251
PDQ_Closed_Trial_Search_ID
  • 39251
Legacy_Concept_Name
  • Glutaminase-Asparaginase
FULL_SYN
  • Glutaminase-AsparaginasePTNCI
DEFINITION
  • A dual function enzyme derived from bacterial Acinetobacter glutaminasificans used as an adjuvant in chemotherapy. Acinetobacter glutaminase-asparaginase (AGA) possesses both L-glutaminase and L-asparaginase activities, capable of hydrolyzing glutamine and asparagine, thereby disturbing nitrogen supplies for dividing cells. When co-administered with alkylating agent melphalan, which utilizes amino acid transport systems for cellular uptake, depletion of glutamine by AGA appeared to facilitate melphalan uptake and enhance its cytotoxicity.NCI
code
  • C2309
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