About: Prothymosin Alpha     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Prothymosin Alpha
equivalentClass
OMIM_Number
  • 188390
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Prothymosin Alpha
UMLS_CUI
  • C0072442
Legacy_Concept_Name
  • Prothymosin_Alpha
FULL_SYN
  • PTMASYNCI
  • Prothymosin AlphaPTNCI
Swiss_Prot
  • P06454
DEFINITION
  • Prothymosin alpha (111 aa, ~12 kDa) is encoded by the human PTMA gene. This protein may play a role in the regulation of apoptosis.NCI
DesignNote
  • Prothymosin alpha can be cleaved to release thymosin alpha-1. (UniProt)
  • Prothymosin alpha is an abundant mammalian acidic nuclear protein whose expression is related to cell proliferation. An association between ProT alpha levels with increase in risk of death from breast cancer has been noticed.
  • Encoded by human PTMA Gene, 110-aa 12-kDa (precursor) highly acidic (54/111 residues) conserved Prothymosin Alpha may be linked covalently to a small RNA; may be involved in ultraviolet irradiation-induced apoptosis; contains N-terminal thymosin-alpha-1 (28-aa) sequence; and may mediate immune function and confer resistance to opportunistic infections. While PHAP promotes caspase-9 activation after apoptosome formation, PTMA inhibits apoptosome formation and caspase-9 activation; caspase-3 activator PETCM relieves PTMA inhibition of apoptosome formation.
code
  • C2279
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