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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Insulin
equivalentClass
Concept_In_Subset
OMIM_Number
  • 176730
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Hormone
Preferred_Name
  • Insulin
NCI_META_CUI
  • CL026873
Contributing_Source
  • CDISC
ALT_DEFINITION
  • A synthetic or animal-derived form of insulin used in the treatment of diabetes mellitus.CDISC
Legacy_Concept_Name
  • Insulin
FULL_SYN
  • insulinPTNCI-GLOSSCDR0000046187
  • InsulinPTNCI
  • INSULINPTCDISC
Swiss_Prot
  • P01308
DEFINITION
  • Human insulin protein (110 aa, 12 kDa) is encoded by the human insulin (INS) gene. This cytosolic protein, a heterodimer of disulfide-linked alpha and beta chains, is produced in pancreatic islet beta cells. Binding of insulin to its receptor stimulates glucose uptake, accelerates both glycolysis and the pentose phosphate cycle and increases glycogen synthesis in the liver. Insulin regulates protein and lipid metabolism. It also decreases blood glucose concentration by shuttling molecules into cells to be used for energy. Decreased expression of insulin protein causes familial hyperproinsulinemia.NCI
code
  • C2271
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