About: Recombinant Interferon Alfa

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Attributes	Values
rdf:type	Class
rdfs:label	Recombinant Interferon Alfa
rdfs:subClassOf	Angiogenesis Activator Inhibitor Recombinant Interferon
Semantic_Type	Amino Acid, Peptide, or Protein Pharmacologic Substance
Preferred_Name	Recombinant Interferon Alfa
UMLS_CUI	C1622507
Accepted_Therapeutic_Use_For	See specific agents.
In_Clinical_Trial_For	See specific agents.
PDQ_Open_Trial_Search_ID	40467
PDQ_Closed_Trial_Search_ID	40467
Legacy_Concept_Name	Therapeutic_Interferon_Alfa
FULL_SYN	Interferon AlfaSYNCI Lymphoblast InterferonSYNCI Lymphoblastoid InterferonSYNCI Alpha InterferonSYNCI alpha-InterferonSYNCI Recombinant Interferon AlfaPTNCI AlferonBRNCI Interferon AlfaPTDCP20108 Leukocyte InterferonSYNCI
DEFINITION	A class of naturally-isolated or recombinant therapeutic peptides used as antiviral and anti-tumor agents. Alpha interferons are cytokines produced by nucleated cells (predominantly natural killer (NK) leukocytes) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes containing an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral effects (viral protein synthesis); antiproliferative effects (cellular growth inhibition and alteration of cellular differentiation); anticancer effects (interference with oncogene expression); and immune-modulating effects (natural killer cell activation, alteration of cell surface antigen expression, and augmentation of lymphocyte and macrophage cytotoxicity). (NCI04)NCI
code	C225
is rdfs:subClassOf of	INTERFERON ALFACON-1 INTERFERON ALFA-2A Interferon Alfa-N1 INTERFERON ALFA-3N Recombinant Interferon Alfa-1b Natural IFN-alpha OPC-18 Recombinant Interferon Alpha 2b-like Protein Multi-subtype Natural Human Leukocyte Interferon Alpha INTERFERON ALFA-2B Pegylated Interferon Alfa Albinterferon Alfa-2b
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