About: PSA RNA-Pulsed Dendritic Cell Vaccine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • PSA RNA-Pulsed Dendritic Cell Vaccine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
  • Immunologic Factor
Preferred_Name
  • PSA RNA-Pulsed Dendritic Cell Vaccine
UMLS_CUI
  • C0879395
In_Clinical_Trial_For
  • Metastatic Prostate Cancer.
PDQ_Open_Trial_Search_ID
  • 37808
PDQ_Closed_Trial_Search_ID
  • 37808
Legacy_Concept_Name
  • PSA_RNA-Pulsed_Dendritic_Cell_Vaccine
FULL_SYN
  • PSA RNA-Pulsed Dendritic Cell VaccinePTNCI
DEFINITION
  • An autologous dendritic cell vaccine with potential immunostimulatory activity. Dendritic cells harvested from a prostate cancer patient are transfected with the mRNA encoding for prostate specific antigen (PSA), a tumor marker secreted by prostatic epithelial and ductal cells. When reintroduced back to the patient, these PSA RNA pulsed autologous dendritic cells may elicit a cytotoxic T-cell (CTL) response against PSA-positive prostate cancer cells.NCI
code
  • C2236
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