About: Zosuquidar Trihydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Zosuquidar Trihydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Zosuquidar Trihydrochloride
NSC_Code
  • 725086
UMLS_CUI
  • C0528372
CAS_Registry
  • 167465-36-3
In_Clinical_Trial_For
  • Acute Myeloid Leukemia and Refractory Anemia
FDA_UNII_Code
  • 813AGY3126
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of cancer. Zosuquidar trihydrochloride may help kill cancer cells that are resistant to anticancer drugs.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 43659
PDQ_Closed_Trial_Search_ID
  • 43659
Chemical_Formula
  • C32H31F2N3O2.3ClH
Legacy_Concept_Name
  • Zosuquidar_Trihydrochloride
FULL_SYN
  • Zosuquidar TrihydrochloridePTNCI
  • zosuquidar trihydrochloridePTNCI-GLOSSCDR0000257971
  • LY335979PTNCI-GLOSSCDR0000046762
  • (R)-4-((1aR,6R,10bS)-1,2-Difluoro-1,1a,6,10b-tetrahydrodibenzo(a,e)cyclopropa(c)cycloheptan-6-yl)-alpha-((5-quinoloyloxy)methyl)-1-piperazineethanol, TrihydrochlorideSNNCI
  • LY335979CNNCI
  • ZOSUQUIDAR TRIHYDROCHLORIDEPTFDA813AGY3126
DEFINITION
  • A difluorocyclopropyl quinoline. Zosuquidar trihydrochloride binds with high affinity to P-glycoprotein and inhibits P-glycoprotein-mediated multidrug resistance (MDR). P-glycoprotein, encoded by the MDR-1 gene, is a member of the ATP-binding cassette superfamily of transmembrane transporters and prevents the intracellular accumulation of many natural product-derived cytotoxic agents. (NCI04)NCI
code
  • C2225
is someValuesFrom of
is Has_Salt_Form of
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