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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • CC-1088
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • CC-1088
UMLS_CUI
  • C0879595
In_Clinical_Trial_For
  • B-cell Lymphocytic Leukemia
  • Myelodysplastic Syndromes
ALT_DEFINITION
  • A drug that is being studied in the treatment of cancer. It is similar but not identical to thalidomide. CC-1088 belongs to the family of drugs called angiogenesis inhibitors.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 38051
PDQ_Closed_Trial_Search_ID
  • 38051
Legacy_Concept_Name
  • CC-1088
FULL_SYN
  • CC-1088PTNCI-GLOSSCDR0000044967
  • CC-1088CNNCI
  • CC-1088PTNCI
DEFINITION
  • An analog of thalidomide with potential antineoplastic activity that belongs to the functional class of agents called selective cytokine inhibitory drugs (SelCIDs). SelCIDs inhibit phosphodiesterase-4 (PDE 4), an enzyme involved in tumor necrosis factor alpha (TNF alpha) production. CC-1088 inhibits production of the cytokines vascular endothelial growth factor (VEGF) (a pro-angiogenic factor) and interleukin-6 (IL-6). (NCI04)NCI
code
  • C2210
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