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AttributesValues
rdf:type
rdfs:label
  • Proteasome Inhibitor
rdfs:subClassOf
Semantic_Type
  • Chemical Viewed Functionally
Preferred_Name
  • Proteasome Inhibitor
UMLS_CUI
  • C1443643
ALT_DEFINITION
  • A drug that blocks the action of proteasomes. A proteasome is a large protein complex that helps destroy other cellular proteins when they are no longer needed. Proteasome inhibitors are being studied in the treatment of cancer.NCI-GLOSS
Legacy_Concept_Name
  • Proteasome_Inhibitor
CHEBI_ID
  • CHEBI:52726
FULL_SYN
  • proteasome inhibitorPTNCI-GLOSSCDR0000393541
  • Proteasome InhibitorPTNCI
DEFINITION
  • Any substance that inhibits the proteasome complex, an enzyme complex responsible for degradation of ubiquitinated proteins. Inhibition of proteasome activity and ubiquitin-proteasome mediated proteolysis results in an accumulation of poly-ubiquitinated proteins, which may result in the disruption of cellular processes, cell cycle arrest, the induction of apoptosis, and the inhibition of tumor growth and angiogenesis.NCI
code
  • C2160
is rdf:first of
is rdfs:subClassOf of
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