About: Dihydrofolate Reductase Inhibitor

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About: Dihydrofolate Reductase Inhibitor Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Class
rdfs:label	Dihydrofolate Reductase Inhibitor
rdfs:subClassOf	Enzyme Inhibitor
Semantic_Type	Chemical Viewed Functionally
Preferred_Name	Dihydrofolate Reductase Inhibitor
UMLS_CUI	C2911817
Legacy_Concept_Name	Dihydrofolate_Reductase_Inhibitor
FULL_SYN	Dihydrofolate Reductase InhibitorPTNCI DHFR InhibitorSYNCI
DEFINITION	Any substance that inhibits dihydrofolate reductase, an enzyme that catalyzes the conversion of dihydrofolate to tetrahydrofolate, an essential reaction for de novo glycine and purine synthesis. Inhibition of dihydrofolate reductase interferes with DNA and protein synthesis.NCI
code	C2153
is rdf:first of	nodeID://b738082
is rdfs:subClassOf of	Metoprine TRIMETREXATE Methotrexate-E Therapeutic Implant PROGUANIL Ketotrexate Trimethoprim Hydrochloride Piritrexim Triazinate TRIMETREXATE GLUCURONATE METHOTREXATE SODIUM Pralatrexate Aminopterin Emofolin Sodium Talotrexin Proguanil Hydrochloride METHOTREXATE Epiroprim Iclaprim Aditoprim Etoprine Brodimoprim Aminopterin Sodium Ormetoprim Tetroxoprim PYRIMETHAMINE Talotrexin Ammonium Cycloguanil Piritrexim Isethionate Dichloromethotrexate

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