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AttributesValues
rdf:type
rdfs:label
  • Dihydrofolate Reductase Inhibitor
rdfs:subClassOf
Semantic_Type
  • Chemical Viewed Functionally
Preferred_Name
  • Dihydrofolate Reductase Inhibitor
UMLS_CUI
  • C2911817
Legacy_Concept_Name
  • Dihydrofolate_Reductase_Inhibitor
FULL_SYN
  • Dihydrofolate Reductase InhibitorPTNCI
  • DHFR InhibitorSYNCI
DEFINITION
  • Any substance that inhibits dihydrofolate reductase, an enzyme that catalyzes the conversion of dihydrofolate to tetrahydrofolate, an essential reaction for de novo glycine and purine synthesis. Inhibition of dihydrofolate reductase interferes with DNA and protein synthesis.NCI
code
  • C2153
is rdf:first of
is rdfs:subClassOf of
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