About: Purine Nucleoside Phosphorylase Inhibitor     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Purine Nucleoside Phosphorylase Inhibitor
rdfs:subClassOf
Semantic_Type
  • Chemical Viewed Functionally
Preferred_Name
  • Purine Nucleoside Phosphorylase Inhibitor
UMLS_CUI
  • C1514609
Legacy_Concept_Name
  • Purine_Nucleoside_Phosphorylase_Inhibitor
CHEBI_ID
  • CHEBI:63090
FULL_SYN
  • Purine Nucleoside Phosphorylase InhibitorPTNCI
DEFINITION
  • Any substance that inhibits purine nucleoside phosphorylase, an enzyme involved in the purine salvage pathway that metabolizes adenosine into adenine, inosine into hypoxanthine, and guanosine into guanine. Inhibition of purine nucleoside phosphorylase results in accumulation of dGTP and the subsequent failure of DNA synthesis, with its greatest effect in T-cells.NCI
code
  • C2151
is rdfs:subClassOf of
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