About: Breast Cancer Anti-Estrogen Resistance 3 Protein

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Attributes	Values
rdf:type	Class
rdfs:label	Breast Cancer Anti-Estrogen Resistance 3 Protein
rdfs:subClassOf	Cell Cycle Proteins nodeID://b651614 nodeID://b651615 nodeID://b651616 nodeID://b651617 nodeID://b651618 nodeID://b651619 nodeID://b651620 nodeID://b651621 nodeID://b651622 nodeID://b651623 nodeID://b651624 nodeID://b651625
OMIM_Number	604704
Semantic_Type	Amino Acid, Peptide, or Protein Biologically Active Substance
Preferred_Name	Breast Cancer Anti-Estrogen Resistance 3 Protein
UMLS_CUI	C1309026
Legacy_Concept_Name	Breast_Cancer_Anti-Estrogen_Resistance-3_Protein
FULL_SYN	BCAR3SYNCI Breast Cancer Anti-Estrogen Resistance 3 ProteinPTNCI Novel SH2-Containing Protein 2SYNCI Breast Cancer Anti-Estrogen Resistance 3SYNCI SH2 Domain-Containing Protein 3BSYNCI
Swiss_Prot	O75815
DEFINITION	Breast cancer anti-estrogen resistance protein 3 (825 aa, ~93 kDa) is encoded by the human BCAR3 gene. This protein may be involved in receptor-mediated signaling.NCI
DesignNote	Encoded by human BCAR3 Gene, the 92.6 kD 825-amino acid BCAR3 Protein contains a putative SH2 domain, a hallmark of tyrosine kinase signaling molecules, and sequences homologous to CDC48 (Yeast). Abundant expression is seen in heart, placenta, skeletal muscle, spleen, prostate, testis, ovary, small intestine, colon, fetal kidney, and several cancer cell lines, but not in nonmalignant breast tissue. NSP2 induces anti-estrogen resistance in estrogen-dependent breast tumors. (SWISS-PROT, OMIM)
code	C21496

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