About: Bone Morphogenetic Protein 7     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Bone Morphogenetic Protein 7
equivalentClass
OMIM_Number
  • 112267
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Bone Morphogenetic Protein 7
UMLS_CUI
  • C0083867
Legacy_Concept_Name
  • Bone_Morphogenetic_Protein-7
FULL_SYN
  • OP-1SYNCI
  • BMP7SYNCI
  • BMP-7SYNCI
  • Bone Morphogenetic Protein 7PTNCI
  • Osteogenic Protein 1SYNCI
Swiss_Prot
  • P18075
DEFINITION
  • Bone Morphogenetic Protein 7 (BMP7), encoded by the BMP7 gene, is a member of the TGF-beta family. BMP7 signals through receptor serine/threonine kinases and has very strong similarity to murine Bmp7. BMP7 plays a role in calcium regulation and bone homeostasis. It induces cartilage and bone formation and may be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. BMP7 is expressed in the kidney and bladder and lower levels are seen in the brain. At all anatomical sites disrupted by Holt-Oram syndrome mutations, BMP7 is expressed in all structures that are altered in Holt-Oram Syndrome patients, including the heart, proximal and distal forelimb, clavicle, and scapula, as well as other unaffected tissues. (NCI)NCI
code
  • C21358
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