About: Alpha-1A Adrenergic Receptor     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Alpha-1A Adrenergic Receptor
equivalentClass
OMIM_Number
  • 104221
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Alpha-1A Adrenergic Receptor
UMLS_CUI
  • C0389726
Legacy_Concept_Name
  • Alpha-1A_Adrenergic_Receptor
FULL_SYN
  • ADRA1ASYNCI
  • ADRA1CSYNCI
  • ADRA1L1SYNCI
  • Adrenergic, Alpha-1C-, ReceptorSYNCI
  • Alpha-1A Adrenergic ReceptorPTNCI
  • Alpha-1C Adrenergic ReceptorSYNCI
  • Adrenergic, Alpha-1A-, ReceptorSYNCI
  • Alpha 1A-AdrenoceptorSYNCI
Swiss_Prot
  • P35348
DEFINITION
  • Alpha-1A adrenergic receptor (466 aa, 51 kD) is a cell division process protein that is encoded by the human ADRA1A gene and has roles in smooth muscle contraction, regulation of cell proliferation, apoptosis and signal transduction.NCI
DesignNote
  • Alpha-1A-adrenergic receptor, encoded by the ADRA1A gene, regulates smooth muscle contraction, cellular growth and apoptosis. Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This alpha-adrenergic receptor mediates its action by association with g proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(Q) and G(11) proteins. Alternative splicing of the ADRA1A gene generates 4 transcript variants, which encode 4 different isoforms with distinct C termini but having similar ligand binding properties. Its carboxyl-terminal SER or THR residues may be phosphorylated. (From LocusLink, Swiss_Prot and NCI)
code
  • C21285
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