About: E3 Ubiquitin Ligase

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	E3 Ubiquitin Ligase
rdfs:subClassOf	Ligases nodeID://b668248
Semantic_Type	Enzyme
Preferred_Name	E3 Ubiquitin Ligase
NCI_META_CUI	CL415408
Legacy_Concept_Name	E3_Ubiquitin_Ligase
FULL_SYN	E3 Ubiquitin LigasePTNCI
DEFINITION	E3 Ubiquitin Ligases are ATP-dependent enzymes that catalyze the formation of a covalent bond between ubiquitous intracellular Ubiquitin proteins and other proteins, often to mark them for nonlysosomal proteasomal degradation or targeted transport. Ubiquitination requires sequential action of an activating enzyme (E1), a conjugating enzyme (E2), and a ligase (E3). Ubiquitin is coupled to protein by a peptide bond between the ubiquitin C-terminal glycine and protein lysine alpha-amino groups. Ubiquitination regulates protein degradation, chromatin remodeling, cell cycle progression, differentiation, gene expression, stress response, ribosome biogenesis, antigen presentation, apoptosis, signal transduction, transcriptional activation, biological clocks, receptor down regulation, and endocytosis.NCI
code	C21254
is rdf:first of	nodeID://b730834 nodeID://b730835 nodeID://b730836 nodeID://b730837 nodeID://b730838 nodeID://b730839 nodeID://b730840 nodeID://b730841 nodeID://b730842 nodeID://b730843 nodeID://b730844 nodeID://b730845 nodeID://b730846 nodeID://b730847 nodeID://b730848 nodeID://b730849 nodeID://b730850 nodeID://b730851
is rdfs:subClassOf of	E3 Ubiquitin-Protein Ligase MIB1 E3 Ubiquitin-protein Ligase NEDD4 Protein Probable E3 Ubiquitin-Protein Ligase MYCBP2 E3 Ubiquitin-Protein Ligase SIAH2
is someValuesFrom of	nodeID://b649150 nodeID://b649568 nodeID://b661729 nodeID://b661762 nodeID://b668174 nodeID://b668186 nodeID://b668191 nodeID://b668205 nodeID://b668215 nodeID://b668226 nodeID://b668235 nodeID://b668247 nodeID://b670010 nodeID://b689658 nodeID://b694893 nodeID://b694902 nodeID://b704305 nodeID://b704795 nodeID://b712588 nodeID://b724184

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