About: Stromal Interaction Molecule 1

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rdf:type	Class
rdfs:label	Stromal Interaction Molecule 1
rdfs:subClassOf	Transmembrane Protein nodeID://b716083 nodeID://b716084 nodeID://b716085 nodeID://b716086 nodeID://b716087 nodeID://b716088 nodeID://b716089 nodeID://b716090 nodeID://b716091 nodeID://b716092 nodeID://b716093
OMIM_Number	605921
Semantic_Type	Amino Acid, Peptide, or Protein Biologically Active Substance
Preferred_Name	Stromal Interaction Molecule 1
UMLS_CUI	C1430594
Legacy_Concept_Name	Stromal_Interaction_Molecule-1
FULL_SYN	STIM1SYNCI Stromal Interaction Molecule 1PTNCI
Swiss_Prot	Q13586
DEFINITION	Encoded by human STIM1 Gene, ubiquitously expressed 685-amino acid 77.5 kD (precursor) Stromal Interaction Molecule 1 Protein is a potential glycosylated cell surface type 1 transmembrane protein that influences the survival or proliferation of B cell precursors and may act as an adhesion molecule in hematopoiesis by mediating attachment to stromal cells. Phosphorylated mainly on serine residues, the protein contains a predicted signal peptide, a transmembrane helix, and one SAM domain. STIM1 oligomerizes with STIM2 and cell binding may require Mn(II). Defects in STIM1 may cause rhabdomyosarcoma and rhabdoid tumors. (NCI)NCI
code	C21219

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