About: Synuclein Gamma     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Synuclein Gamma
rdfs:subClassOf
OMIM_Number
  • 602998
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Biologically Active Substance
Preferred_Name
  • Synuclein Gamma
UMLS_CUI
  • C0753208
Legacy_Concept_Name
  • Synuclein_Gamma
FULL_SYN
  • SNCGSYNCI
  • Synuclein GammaPTNCI
  • Gamma-SynucleinSYNCI
  • Breast Cancer-Specific Gene 1 ProteinSYNCI
  • PersynSYNCI
  • SynoretinSYNCI
  • Breast Cancer-Specific Protein 1SYNCI
Swiss_Prot
  • O76070
DEFINITION
  • Encoded by human SNCG Gene (Synuclein Family), the highly conserved 127-amino acid 13 kD cytoplasmic Gamma-Synuclein is similar to the amyloid protein nonamyloid beta fragment and to alpha-synuclein and beta-synuclein. SNCG is expressed in brain, heart, skeletal muscle, ovary, testis, colon, spleen, pancreas, kidney and lung. Gamma-Synuclein seems to play a role in neurofilament network integrity and may modulate axonal architecture; it may increase the susceptibility of neurofilament-H to calcium-dependent proteases and may also modulate the keratin network in skin. Phosphorylation by GRK5 appears to occur on residues distinct from other kinase target residues. Gamma-Synuclein is likely involved in the pathogenesis of neurodegenerative diseases and SNCG is expressed at very high level in advanced infiltrating breast cancer. (from Swiss-Prot, OMIM, and NCI)NCI
code
  • C21218
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