About: MRE11/RAD50 Double-Strand Break Repair Complex     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • MRE11/RAD50 Double-Strand Break Repair Complex
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • MRE11/RAD50 Double-Strand Break Repair Complex
UMLS_CUI
  • C1334529
Legacy_Concept_Name
  • MRE11-RAD50_Double-Strand_Break_Repair_Complex
FULL_SYN
  • MRE11/RAD50 Double-Strand Break Repair ComplexPTNCI
DEFINITION
  • The MRE11/RAD50 double-strand break repair complex consists of 5 proteins: Nibrin, p200, p400, MRE11, and RAD50. This complex possesses manganese-dependent single-stranded DNA endonuclease and 3-prime to 5-prime exonuclease activities. In mammalian cells, this complex is important for double-strand break repair, meiotic recombination, and telomere maintenance. It functions in diverse aspects of the cellular response to double strand breaks (DSBs), including the detection of DNA damage, the activation of cell cycle checkpoints, and DSB repair. (from OMIM)NCI
code
  • C21177
is someValuesFrom of
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