About: Epidermal Growth Factor Superfamily Protein     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Epidermal Growth Factor Superfamily Protein
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Epidermal Growth Factor Superfamily Protein
UMLS_CUI
  • C1333412
Legacy_Concept_Name
  • Epidermal_Growth_Factor_Superfamily_Protein
FULL_SYN
  • Epidermal Growth Factor Repeat SuperfamilySYNCI
  • EGF Repeat SuperfamilySYNCI
  • Epidermal Growth Factor Superfamily ProteinPTNCI
DEFINITION
  • Many Epidermal Growth Factor Superfamily Proteins are extracellular signaling molecules (ligands) involved in control of target cell proliferation, cell survival, and cell differentiation. The EGF superfamily is characterized by having at least 6 cysteines residues that form disulphide bonds stacked in a ladder-like arrangement, in the order 1-3, 2-4, 5-6, and which are essential for the stability of the EGF fold. Often arranged as tandem repeats in extracellular proteins, the function of the domains remains unclear, but are thought to perform a structural role.NCI
code
  • C20970
is rdf:first of
is rdfs:subClassOf of
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