About: Rho Guanine Nucleotide Exchange Factor 1     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Rho Guanine Nucleotide Exchange Factor 1
equivalentClass
OMIM_Number
  • 601855
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Rho Guanine Nucleotide Exchange Factor 1
UMLS_CUI
  • C0606872
Legacy_Concept_Name
  • Rho_Guanine_Nucleotide_Exchange_Factor-1
FULL_SYN
  • ARHGEF1SYNCI
  • Rho Guanine Nucleotide Exchange Factor 1PTNCI
  • Rho GEF 1SYNCI
Swiss_Prot
  • Q92888
DEFINITION
  • Ubiquitously expressed by human ARHGEF1 Gene as alternative isoforms 1 (912-aa, 102-kD) and 2 (879-aa), cytoplasmic Rho Guanine Nucleotide Exchange Factor 1 contains a (homooligomerizing) coiled coil region, a DH domain, a PH domain, and an RGSL domain (necessary for GAP activity). Responsive to extracellular stimuli acting through GPCRs, ARHGEF1 may complex with G proteins and regulates cell cycle and cell proliferation activity. Phosphorylated by PKCA and translocated to the plasma membrane by stimulation, ARHGEF1 seems to regulate RHOA GTPase signal transduction as a GEF and GNA12 and GNA13 (RGS domain interaction) as a GAP. ARHGEF1 GEF activity is inhibited by binding to activated GNA12. (NCI)NCI
code
  • C20942
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