About: Cystatin Superfamily Gene     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Cystatin Superfamily Gene
rdfs:subClassOf
Semantic_Type
  • Gene or Genome
Preferred_Name
  • Cystatin Superfamily Gene
UMLS_CUI
  • C1333186
Legacy_Concept_Name
  • Cystatin_Superfamily_Gene
FULL_SYN
  • Cystatin Superfamily GenePTNCI
DEFINITION
  • Cystatin Superfamily Genes comprise a single evolutionary superfamily that encode protein subfamilies with functional and structural similarities that include cystatin-like sequences: Stefins (Type 1 Cystatins), Cystatins (Type 2 Cystatins), and Kininogens. Some members are active cysteine protease inhibitors; others have lost or never acquired inhibitory activity. Cystatins are intracellular or extracellular, tight, reversible, competitive inhibitors of lysosomal cysteine proteinases, such as Cathepsins B, L, H, and S, that appear to provide a protective function. Type 1 Cystatins lack disulfide bridges. Type 2 Cystatins are secreted and have 2 intrachain disulfide bonds. Kininogens contain 3 cystatin-like domains, each with 2 disulfide bonds. (NCI)NCI
code
  • C20726
is rdfs:subClassOf of
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