About: TFIIE Subunit Gene     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • TFIIE Subunit Gene
rdfs:subClassOf
Semantic_Type
  • Gene or Genome
Preferred_Name
  • TFIIE Subunit Gene
UMLS_CUI
  • C1336613
Legacy_Concept_Name
  • TFIIE_Subunit_Gene
FULL_SYN
  • TFIIE Subunit GenePTNCI
DEFINITION
  • TFIIE Subunit Genes encode 2 subunit proteins of 56 kD and 34 kD. TFIIE is a heterotetramer of 2 alpha and 2 beta subunits, both subunits being required for optimal basal-level transcription. Both subunits are essential to form a stable preinitiation complex. High levels of gene transcription by RNA polymerase II depend on high rates of transcription initiation and reinitiation. Initiation requires recruitment of the complete transcription machinery to a promoter, a process facilitated by activators and chromatin remodeling factors. Reinitiation occurs through a different pathway. After initiation, a subset of the transcription machinery remains at the promoter, forming a platform for assembly of a second transcription complex as a scaffold for formation of a functional reinitiation complex. Formation of this scaffold depends on ATP and TFIIH. Some activators and Mediator may promote high levels of transcription. (from OMIM 189962).NCI
code
  • C20647
is rdfs:subClassOf of
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