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AttributesValues
rdf:type
rdfs:label
  • TFIIH
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • TFIIH
UMLS_CUI
  • C0172237
Legacy_Concept_Name
  • TFIIH
FULL_SYN
  • TFIIHPTNCI
DEFINITION
  • TFIIH is a multisubunit factor consisting of at least 5 polypeptides of 92, 62, 43, 40, and 35 kD. The nonphosphorylated form of RNA polymerase II is recruited by TFIIF to the DB complex (a DNA-protein complex composed of the TATA-binding protein subunit of TFIID in association with the TATA motif and TFIIB). This complex is then recognized by TFIIE, TFIIH, and TFIIJ to generate a transcription-competent complex. Phosphorylation of the C-terminal domain of the largest subunit of RNA polymerase II controls the transition from transcription initiation to elongation. The general transcription factor TFIIH contains a kinase activity capable of phosphorylating this domain. Factors that promote the association of RNA polymerase II with the preinitiation complex stimulate this activity. TFIIE, which is required for the stable association of TFIIH with the preinitiation complex, affects the processivity of TFIIH kinase. (from OMIM 189972)NCI
code
  • C20593
is someValuesFrom of
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