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AttributesValues
rdf:type
rdfs:label
  • HMGA Family Gene
rdfs:subClassOf
Semantic_Type
  • Gene or Genome
Preferred_Name
  • HMGA Family Gene
UMLS_CUI
  • C1333907
Legacy_Concept_Name
  • HMGA_Family_Gene
FULL_SYN
  • HMGA Family GenePTNCI
Gene_Encodes_Product
  • HMGA Family Protein
DEFINITION
  • Human HMGA Family Genes encode HMGA proteins that participate in many nuclear processes ranging from chromosome and chromatin mechanics to transcription factors that regulate gene expression. Hence, they influence diverse biological processes including cell growth, proliferation, differentiation and death. HMGA proteins contain three AT-hooks that bind to minor groove AT-rich stretches. HMGA proto-oncogenes promote tumor progression and metastasis when overexpressed. High constitutive HMGA expression is consistently observed in cancers, with increasing concentrations being correlated with increasing malignancy. (NCI)NCI
code
  • C20573
is rdfs:subClassOf of
is someValuesFrom of
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