About: Interferon-alpha Inducible Protein 10     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:DeprecatedClass, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Interferon-alpha Inducible Protein 10
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
  • Immunologic Factor
Preferred_Name
  • Interferon-alpha Inducible Protein 10
OLD_PARENT
  • Alpha Chemokine
OLD_KIND
  • Protein_Kind
Concept_Status
  • Retired_Concept
FULL_SYN
  • IP-10SYNCI
  • Interferon-alpha Inducible Protein 10PTNCI
  • NEX348SYNCI
  • IFN-Gamma-Inducible Protein-10SYNCI
DEFINITION
  • A member of the alpha-chemokine family, IP10 is secreted from macrophages, endothelial cells, and keratinocytes in response to IFN-gamma and activates a G protein coupled receptor. IP10 has homology to PFIV, BTG, CTAP-III, and peptides associated with cell proliferation, is a potent inhibitor of angiogenesis, inhibits bone marrow colony formation, has anti-tumor activity, is a chemoattractant for monocytes and T-cells, promotes T-cell adhesion to endothelial cells, and probably participates in chronic cell-mediated inflammatory reactions. The IP10 gene is a RAS signaling target. (from OMIM 147310 and NCI)NCI
code
  • C20472
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