About: Beta Thromboglobulin

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Attributes	Values
rdf:type	Class
rdfs:label	Beta Thromboglobulin
rdfs:subClassOf	Chemokines, CXC nodeID://b650267 nodeID://b650268 nodeID://b650269 nodeID://b650270 nodeID://b650271 nodeID://b650272 nodeID://b650273
OMIM_Number	121010
Semantic_Type	Amino Acid, Peptide, or Protein
Preferred_Name	Beta Thromboglobulin
UMLS_CUI	C0005286
Legacy_Concept_Name	Beta_Thromboglobulin
FULL_SYN	CXC Chemokine Ligand 7SYNCI bTGSYNCI PPBPSYNCI NAP-2SYNCI Beta TGSYNCI Beta-TGSYNCI Beta ThromboglobulinPTNCI
Swiss_Prot	P02775
DEFINITION	Encoded by human PPBP Gene (Alpha Chemokine CXC Family), secreted 128-aa 14-kDa (precursor) Pro-Platelet Basic Protein is a platelet-derived growth factor that is processed to PBP and CTAP-III. Upon platelet activation, PBP is proteolytically converted to Beta Thromboglobulin, a homotetramer released when platelets aggregate. Proteolytic removal of PPBP residues 1-9 produces active peptide CTAP-III/LA-PF4, which stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan, as well as formation and secretion of plasminogen activator. CTAP-III is also proteolytically converted to NAP2, a potent chemoattractant and activator of neutrophils. (NCI)NCI
code	C20468

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