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AttributesValues
rdf:type
rdfs:label
  • HL-60/MX2
rdfs:subClassOf
Semantic_Type
  • Cell
Preferred_Name
  • HL-60/MX2
UMLS_CUI
  • C1512309
Legacy_Concept_Name
  • HL-60_MX2
FULL_SYN
  • HL-60/MX2PTNCI
DEFINITION
  • HL-60/MX2 is a mitoxantrone resistant derivative of the HL-60 cell line. HL-60/MX2 is approximately 35 fold less sensitive to mitoxantrone than the HL-60 parental cells. HL-60/MX2 cells are cross-resistant to etoposide, teniposide, bisantrene, dactinomycin, 4'-(9-acridinylamino)methane- sulfon-m-anisidide, and the anthracyclines daunorubicin and doxorubicin but retain sensitivity to the Vinca alkaloids vincristine and vinblastine, melphalan, mitomycin C and cisplatin. In addition, the HL-60/MX2 cells display slight collateral sensitivity to bleomycin. Resistance to mitoxantrone is stable for up to six months.NCI
code
  • C20229
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