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AttributesValues
rdf:type
rdfs:label
  • Thymidylate Synthase Inhibitor
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Thymidylate Synthase Inhibitor
UMLS_CUI
  • C1373008
ALT_DEFINITION
  • A drug that blocks DNA synthesis and may prevent tumor cell growth. It is being studied as a treatment for cancer.NCI-GLOSS
Legacy_Concept_Name
  • Thymidylate_Synthase_Inhibitor
CHEBI_ID
  • CHEBI:63720
FULL_SYN
  • thymidylate synthase inhibitorPTNCI-GLOSSCDR0000044832
  • Thymidylate Synthetase InhibitorsSYNCI
  • Thymidylate Synthase InhibitorPTNCI
DEFINITION
  • Any substance that inhibits thymidylate synthase, an enzyme that catalyzes the conversion of uridine monophosphate to thymidine monophosphate, the rate-limiting step in de novo production of dTMP. Inhibition of thymidylate synthase causes inhibition of DNA synthesis and cell proloferation.NCI
code
  • C2021
is rdf:first of
is rdfs:subClassOf of
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