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AttributesValues
rdf:type
rdfs:label
  • Swh3p
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Biologically Active Substance
Preferred_Name
  • Swh3p
UMLS_CUI
  • C1455624
Legacy_Concept_Name
  • Swh3p
FULL_SYN
  • Rsc8SYNCI
  • Swh3SYNCI
  • Swh3pPTNCI
  • YFR037CSYNCI
  • Rsc8/Swh3SYNCI
DEFINITION
  • A subunit of unknown function in the fifteen-protein RSC nucleosome/chromatin remodeling complex, Rsc8/Swh3 is a homolog of the SWI/SNF protein SWI3. Swi3/BAF155 contains a leucine zipper motif typical of many transcription factors. Swh3p undergoes dimerization via the coiled-coil C-terminus, forms a complex with RSC6p, interacts with the SWI2/SNF2 ATPase Sth1p, and appears to mediate multiple RSC interactions. SWI/SNF and RSC share conserved components. SWI/SNF proteins display helicase and ATPase activities and appear to regulate gene transcription by altering local chromatin structure. RSC complex is required for transcriptional regulation and nucleosome positioning. RSC maintains a repressive chromatin structure at certain inducible promoters. (from SGD; NAR 26:3739, 1998; EMBO J. 18:2836, 1999; and NCI)NCI
DesignNote
  • Homologous_Protein: BAF155
  • Protein_Family: SWI Family
  • Protein_Interacts_With: Rsc6, Sth1
  • SGDID S0001933
code
  • C19854
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