About: Negative Regulation of G1 Phase

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Attributes	Values
rdf:type	Class
rdfs:label	Negative Regulation of G1 Phase
rdfs:subClassOf	G1 Phase Process nodeID://b674847
Semantic_Type	Phenomenon or Process
Preferred_Name	Negative Regulation of G1 Phase
UMLS_CUI	C1517342
Legacy_Concept_Name	G1_Arrest
FULL_SYN	G1 BlockSYNCI Negative Regulation of G1 PhasePTNCI G1 ArrestSYNCI
DEFINITION	G1 Arrest consists of cellular biochemical mechanisms, responsive to diverse governing conditions (DNA damage, contact inhibition, growth factors, etc.), that control cellular progress through the G1 phase of the cell cycle. G1 progress is controlled by de/phosphorylated cyclin/CDK complexes. During G1, cycD/CDK phosphorylation of Rb/HDAC repressor permits E2F/DP1 transcription of genes that promote the G1/S switch and DNA replication. p53 induces p21 inhibition of cycD/CDK; Mdm2 inhibits p53/p21. TGF-b induces p15 inhibition of cycD/CDK. cAMP induces p27 inhibition of cycD/CDK. GSK3b induction of cycD degradation, and INK4, Kip, and Cdc25A regulate cycD/CDK activity.NCI
code	C19816
is someValuesFrom of	nodeID://b645203 nodeID://b652764 nodeID://b653989 nodeID://b654034 nodeID://b654243 nodeID://b662117 nodeID://b662146 nodeID://b673654 nodeID://b698928 nodeID://b701020 nodeID://b701039 nodeID://b702373 nodeID://b705957 nodeID://b711860 nodeID://b712144

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