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AttributesValues
rdf:type
rdfs:label
  • Genotoxic Stress
rdfs:subClassOf
Semantic_Type
  • Phenomenon or Process
Preferred_Name
  • Genotoxic Stress
UMLS_CUI
  • C1257899
Legacy_Concept_Name
  • Genotoxic_Stress
FULL_SYN
  • Genotoxic StressPTNCI
DEFINITION
  • Exposure to DNA-damaging agents and subsequent energy expenditures by a cell to repair DNA damage. Genotoxic stress elicits biochemical responses that either enhance cell survival or lead to cell death. These biochemical responses include DNA-damage-inducible repair and increasing expression of a variety of proteins by both transcriptional and post-transcriptional mechanisms. Genotoxic stresses frequently activate signal transduction pathways that originate in the cell membrane or cytoplasm, triggering similar phosphorylation cascades to those induced by the activation of cell-surface receptors.NCI
code
  • C19419
is rdfs:subClassOf of
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