About: Adenosine Receptor     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:DeprecatedClass, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Adenosine Receptor
rdfs:subClassOf
Semantic_Type
  • Receptor
Preferred_Name
  • Adenosine Receptor
OLD_PARENT
  • Purinergic-P1_Receptor
OLD_CHILD
  • Adenosine-A1_Receptor
  • Adenosine-A2A_Receptor
  • Adenosine-A2B_Receptor
  • Adenosine-A3_Receptor
OLD_ROLE
  • Gene_Product_Plays_Role_In_Biological_Process some 'Intercellular Communication Process'
  • Gene_Product_Plays_Role_In_Biological_Process some 'G Protein-Coupled Receptor Signaling'
NCI_META_CUI
  • CL414397
Concept_Status
  • Retired_Concept
Legacy_Concept_Name
  • Adenosine_Receptor
FULL_SYN
  • Adenosine ReceptorPTNCI
DEFINITION
  • One of the purinergic P1 receptors that prefers adenosine to other endogenous purines.NCI
  • The three conserved (GPCR Family) widely expressed types of Adenosine Receptors (A1, A2, A3) exhibit specific patterns of ligand binding and unique tissue distributions. Each cell-surface integral membrane protein receptor contains a 7 transmembrane domain and interacts with a heterotrimeric G protein complex in response to adenosine ligand to stimulate or suppress cAMP accumulation through adenylate cyclase activation or inhibition. Regulating diverse physiologic functions (cardiac rate and contractility, smooth muscle tone, sedation, release of neurotransmitters, platelet function, lipolysis, renal function, white blood cell function, and spermatozoal capacitation), adenosine receptors modulate the activity of neuronal populations, platelets, neutrophils, and mast cells, and smooth muscle cells in bronchi and vasculature. A potent biologic mediator, most effects of adenosine protect cells during stress.NCI
DesignNote
  • Fri Aug 05 12:26:58 EDT 2011 - See 'Purinergic-P1_Receptor'
code
  • C19331
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