About: Thymic T-Cell Selection

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Attributes	Values
rdf:type	Class
rdfs:label	Thymic T-Cell Selection
rdfs:subClassOf	T-Cell Differentiation in the Thymus
Semantic_Type	Cell Function
Preferred_Name	Thymic T-Cell Selection
UMLS_CUI	C1515433
Legacy_Concept_Name	Thymocyte_Selection
FULL_SYN	Thymic T-Cell SelectionPTNCI Thymocyte SelectionSYNCI
DEFINITION	Bone marrow-derived stem cells in the thymus become educated to recognize complexes of self-major histocompatibility complex (MHC) molecules plus self-peptides in a process called positive selection under the influence of epithelial cells in the thymic cortex. Positively-selected thymic T cell precursors (thymocytes) then progress through a process called negative selection under the influence of bone marrow-derived dendritic cells at the corticomedullary junction where self-reactive, and potentially autoimmunity-inducing, thymocytes are deleted. Thymocytes simultaneously progress through phases expressing both CD4 and CD8 coreceptors to a single positive stage expressing only CD4 or CD8 in addition to the T cell receptor. They are then allowed to leave the thymus and enter the periphery via the lymphatics or venules of the circulatory system as mature T cells.NCI
code	C19064
is someValuesFrom of	nodeID://b646436 nodeID://b660813 nodeID://b716792

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