About: T-Cell Receptor Activation     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • T-Cell Receptor Activation
rdfs:subClassOf
Semantic_Type
  • Molecular Function
Preferred_Name
  • T-Cell Receptor Activation
UMLS_CUI
  • C1515144
Legacy_Concept_Name
  • TCR_Activation
FULL_SYN
  • TCR ActivationSYNCI
  • TCR InteractionSYNCI
  • T-Cell Receptor ActivationPTNCI
  • T-Cell Receptor InteractionSYNCI
DEFINITION
  • Any process in which a specific pair of interactions is observed between a T cell and an antigen-presenting cell, where the interactions include those between the T cell receptor and the major histocompatibility complex and those between CD28 and B7 family members. This process is involved in anergy and specification of the immune response to a particular antigen.NCI
DesignNote
  • TCR Activation during T cell development and proliferation involves binding to specific antigen by Ig-like heterodimeric transmembrane surface alpha/beta (antigen/MHC) or gamma/delta (antigen) glycoprotein receptors non-covalently associated with CD3 complex on T lymphocytes. Antigen-bound TCRs activate MAPKs and JNK1 through CD3 antigens, adaptor protein LAT, and tyrosine kinases LCK and ZAP70.
code
  • C19060
is someValuesFrom of
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