About: Brivudine Phosphoramidate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Brivudine Phosphoramidate
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • Brivudine Phosphoramidate
UMLS_CUI
  • C0964443
In_Clinical_Trial_For
  • Colorectal cancer
ALT_DEFINITION
  • A substance that is being studied for its ability to make cancer cells respond to drugs to which they have become resistant. It is a type of nucleoside analog.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 38549
PDQ_Closed_Trial_Search_ID
  • 38549
Legacy_Concept_Name
  • NB1011
FULL_SYN
  • (E)-5-(2-Bromovinyl)-2'-deoxy-5'-uridyl Phenyl L-methoxyalaninylphosphoramidateSNNCI
  • ThymectacinBRNCI
  • BVDU ProdrugSYNCI
  • Brivudine PhosphoramidatePTNCI
  • NB1011PTNCI-GLOSSCDR0000045075
  • NB1011CNNCI
  • NB101.1CNNCI
  • BVdU PhosphoramidateSYNCI
DEFINITION
  • A small molecule phosphoramidate derivative of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVdU) with potential antineoplastic activity. Selectively active against tumor cells expressing high levels of thymidylate synthase (TS), brivudine is converted intracellularly by TS to bromovinyldeoxyuridine monophosphate (BVdUMP) which competes with the natural substrate, deoxyuridine monophosphate, for binding to TS. Unlike TS inhibitors, this agent is a reversible substrate for TS catalysis. Thus, TS retains activity and converts BVdUMP into cytotoxic metabolites. As key enzyme in the de novo synthesis of dTMP, TS is an enzyme critical to DNA biosynthesis and is overexpressed in many solid tumors.NCI
code
  • C1882
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