About: Canertinib Dihydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Canertinib Dihydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Has_Target
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Canertinib Dihydrochloride
UMLS_CUI
  • C0964184
CAS_Registry
  • 289499-45-2
FDA_UNII_Code
  • ICJ93X8X90
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of some types of cancer. Canertinib blocks the action of proteins called epidermal growth factor receptors, and may cause cancer cells to die. It is a type of tyrosine kinase inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 38403
PDQ_Closed_Trial_Search_ID
  • 38403
Chemical_Formula
  • C24H25ClFN5O3.2HCl
Legacy_Concept_Name
  • CI-1033
FULL_SYN
  • canertinibPTNCI-GLOSSCDR0000560928
  • PD-0183805-002BCNNCI
  • Canertinib DihydrochloridePTNCI
  • canertinib dihydrochloridePTNCI-GLOSSCDR0000579644
  • CI-1033PTNCI-GLOSSCDR0000045040
  • N-[-4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide DihydrochlorideSNNCI
  • CI-1033CNNCI
  • PD183805CNNCI
  • CANERTINIB DIHYDROCHLORIDEPTFDAICJ93X8X90
  • N-[-4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide DihydrochloridePTDCP50460
DEFINITION
  • The hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and radiosensitizing activities. Canertinib binds to the intracellular domains of epidermal growth factor receptor tyrosine kinases (ErbB family), irreversibly inhibiting their signal transduction functions and resulting in tumor cell apoptosis and suppression of tumor cell proliferation. This agent also acts as a radiosensitizing agent and displays synergistic activity with other chemotherapeutic agents.NCI
code
  • C1880
is Has_Salt_Form of
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