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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Midostaurin
rdfs:subClassOf
Has_Target
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Midostaurin
UMLS_CUI
  • C0915830
CAS_Registry
  • 120685-11-2
In_Clinical_Trial_For
  • Acute myeloid leukemia; myelodysplasic syndrome
FDA_UNII_Code
  • ID912S5VON
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is being studied in the treatment of leukemia. It belongs to the family of drugs called protein kinase inhibitors.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 462346
PDQ_Closed_Trial_Search_ID
  • 462346
Chemical_Formula
  • C35H30N4O4
Legacy_Concept_Name
  • Midostaurin
CHEBI_ID
  • CHEBI:63452
FULL_SYN
  • N-BenzoylstaurosporineSYNCI
  • MidostaurinPTNCI
  • N-Benzoyl-StaurosporineSYNCI
  • midostaurinPTNCI-GLOSSCDR0000513012
  • PKC412PTNCI-GLOSSCDR0000269425
  • PKC412CNNCI
  • PKC-412CNNCI
  • CGP41251CNNCI
  • MIDOSTAURINPTFDAID912S5VON
  • CGP 41251PTDCP31646
  • N-benzoyl-staurosporinePTNCI-GLOSSCDR0000513009
DEFINITION
  • A synthetic indolocarbazole multikinase inhibitor with potential antiangiogenic and antineoplastic activities. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platelet-derived growth factor receptor (PDGFR) and FMS-like tyrosine kinase 3 (FLT3) tyrosine kinases, which may result in disruption of the cell cycle, inhibition of proliferation, apoptosis, and inhibition of angiogenesis in susceptible tumors.NCI
code
  • C1872
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