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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • BMS-214662
rdfs:subClassOf
Has_Target
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • BMS-214662
NSC_Code
  • 710086
UMLS_CUI
  • C0879424
ALT_DEFINITION
  • A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called farnesyltransferase inhibitors.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 37852
PDQ_Closed_Trial_Search_ID
  • 37852
Legacy_Concept_Name
  • BMS214662
FULL_SYN
  • FTI BMS 214662SYNCI
  • BMS-214662PTNCI-GLOSSCDR0000044889
  • BMS-214662CNNCI
  • BMS-214662PTNCI
DEFINITION
  • A nonsedating benzodiazepine derivative with potential antineoplastic activity. Farnesyltransferase inhibitor BMS-214662 inhibits the enzyme farnesyltransferase and the post-translational farnesylation of number of proteins involved in signal transduction, which may result in the inhibition of Ras function and apoptosis in susceptible tumor cells. This agent may reverse the malignant phenotype of H-Ras-transformed cells and has been shown to be active against tumor cells with and without Ras mutations.NCI
code
  • C1856
is someValuesFrom of
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