About: MYC Family Gene     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • MYC Family Gene
rdfs:subClassOf
Semantic_Type
  • Gene or Genome
Preferred_Name
  • MYC Family Gene
UMLS_CUI
  • C0026902
Legacy_Concept_Name
  • MYC_Family_Gene
FULL_SYN
  • MYC Family GenePTNCI
  • MYC GeneSYNCI
Gene_Encodes_Product
  • MYC Family Protein
DEFINITION
  • MYC Family Genes encode MYC Family Proteins, class III bHLH leucine zipper transcription factors having cellular proliferative and apoptotic roles. Dimerization via leucine zippers of MYC proteins with bHLH/lz proteins, such as MAX, is required for efficient DNA binding. Leucine zippers are present in many gene regulatory proteins, including CREB proteins, Jun/AP1 transcription factors, and FOS-type proteins, as well as MYC proteins. The periodically repeated leucine side chains extending from one alpha helix interdigitate with leucine residues of another alpha helix, facilitating coiled-coil dimerization; like charge repulsion in this region perturbs homodimer formation; heterodimers are promoted by opposing charge attractions. c-MYC transcription factor binds to CAC(GA)TG DNA sites. MYC sequences have been highly conserved throughout evolution, from Drosophila to vertebrates. (NCI)NCI
code
  • C18537
is rdfs:subClassOf of
is someValuesFrom of
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