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AttributesValues
rdf:type
rdfs:label
  • Suramin Sodium
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Has_Target
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Suramin Sodium
NSC_Code
  • 34936
UMLS_CUI
  • C0813205
CAS_Registry
  • 129-46-4
Accepted_Therapeutic_Use_For
  • African trypanosomiasis; onchocerciasis
In_Clinical_Trial_For
  • Bladder cancer; breast cancer; non-small cell lung cancer
FDA_UNII_Code
  • 89521262IH
Contributing_Source
  • FDA
Chemical_Formula
  • C51H34N6O23S6.6Na
Legacy_Concept_Name
  • Suramin_Sodium
FULL_SYN
  • Fourneau 309SYDTPNSC0034936
  • 309 FSYDTPNSC0034936
  • Fourneau 309FBNCI
  • 8,8'-(Carbonylbis(imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino))bis-1,3,5-naphthalenetrisulfonic Acid Hexasodium SaltSNNCI
  • SURAMIN SODIUMPTFDA89521262IH
  • Suramin HexasodiumPTDCP30140
  • Suramin SodiumPTNCI
  • Sodium SuraminSYNCI
  • Sodium suraminSYDTPNSC0034936
  • Suramin sodiumSYDTPNSC0034936
  • NaganinSYDTPNSC0034936
  • NaganolSYDTPNSC0034936
  • MoranylSYDTPNSC0034936
  • 309 FFBNCI
  • GermaninSYDTPNSC0034936
  • AntrypolSYDTPNSC0034936
  • Bayer 205SYDTPNSC0034936
  • CI-1003CNNCI
  • Suramin HexasodiumSYNCI
  • NaganinFBNCI
  • NaganolFBNCI
  • MetaretBRNCI
  • MoranylFBNCI
  • BelganylFBNCI
  • GermaninFBNCI
  • AntrypolFBNCI
  • Bayer 205CNNCI
  • NaganinumFBNCI
  • NaphurideFBNCI
DEFINITION
  • A sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis.NCI
code
  • C1848
is Has_Salt_Form of
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