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AttributesValues
rdf:type
rdfs:label
  • BL22 Immunotoxin
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • BL22 Immunotoxin
NSC_Code
  • 691237
UMLS_CUI
  • C0796473
In_Clinical_Trial_For
  • Chronic lymphocytic leukemia and CD22 positive lymphoma; hairy cell leukemia; B-cell lymphomas and leukemia; non-Hodgkins lymphoma.
ALT_DEFINITION
  • A bacterial toxic substance linked to an antibody that attaches to cancer cells and kills them. It belongs to the family of drugs called bacterial immunotoxins.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 43322
PDQ_Closed_Trial_Search_ID
  • 43322
Legacy_Concept_Name
  • BL22_Immunotoxin
FULL_SYN
  • BL22 Immunotoxin [RFB4(dsFv) - PE38SYNCI
  • RFB4(dsFv)-PE38 ImmunotoxinSYNCI
  • BL22SYNCI
  • BL22 ImmunotoxinPTNCI
  • Immunotoxin BL22SYNCI
  • Anti-CD22 Recombinant Immunotoxin BL22SYNCI
  • BL22 immunotoxinPTNCI-GLOSSCDR0000046175
DEFINITION
  • A recombinant immunotoxin consisting of the Fv portion of the anti-CD22 antibody RFB4 fused to a fragment of Pseudomonas exotoxin-A with potential antineoplastic activity. BL22 immunotoxin binds to CD22, an antigen expressed in B-cell malignancies, thereby delivering its toxin directly to tumor cells. The toxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also blocks translational elongation via binding to elongation factor-2 in eukaryotic cells.NCI
code
  • C1842
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