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AttributesValues
rdf:type
rdfs:label
  • Cilengitide
equivalentClass
Has_Target
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Cilengitide
NSC_Code
  • 707544
UMLS_CUI
  • C0971473
CAS_Registry
  • 188968-51-6
In_Clinical_Trial_For
  • Pediatric refractory primary brain tumors; advanced solid tumors or lymphoma
FDA_UNII_Code
  • 4EDF46E4GI
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is being studied as an anticancer and antiangiogenesis drug.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 37844
PDQ_Closed_Trial_Search_ID
  • 37844
Chemical_Formula
  • C27H40N8O7
Legacy_Concept_Name
  • Cilengitide
FULL_SYN
  • EMD-121974PTDCP31655
  • CilengitidePTNCI
  • cilengitidePTNCI-GLOSSCDR0000315757
  • EMD 121974SYDTPNSC0707544
  • cyclo(L-arginylglycyl-L-a-aspartyl-D-phenylalanyl-N-methyl-L-valyl)SNNCI
  • CILENGITIDEPTFDA4EDF46E4GI
  • EMD 121974PTNCI-GLOSSCDR0000044887
  • EMD 121974CNNCI
DEFINITION
  • A cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis. (NCI04)NCI
code
  • C1834
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