About: Oncogene LCK     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Oncogene LCK
equivalentClass
OMIM_Number
  • 153390
GenBank_Accession_Number
  • M36881
Semantic_Type
  • Gene or Genome
Preferred_Name
  • Oncogene LCK
NCI_META_CUI
  • CL414564
Legacy_Concept_Name
  • Oncogene_LCK
FULL_SYN
  • Oncogene LCKPTNCI
DEFINITION
  • Human Oncogene LCK is a mutated variant of LCK Gene, which encodes p56LCK, a lymphocyte-specific tyrosine protein kinase with an SH2 and SH3 domain. LCK may participate in T-cell activation; p56LCK regulates allelic exclusion at the TCR beta locus. It binds to CD4, CD8 and IL-2R beta chain cytoplasmic domains. p56LCK is quickly activated by mIg cross-linking on B-cells or by TCR cross-linking. Pre-TCR co-localizes with p56LCK kinase in membrane rafts resulting in phosphorylation of CD3-epsilon and ZAP70. p56LCK, in the TCR complex, activates DNA binding of STAT5A and STAT5B. Oncogene LCK disrupts normal cell function.NCI
code
  • C18334
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