About: Tegafur-gimeracil-oteracil Potassium     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Tegafur-gimeracil-oteracil Potassium
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Tegafur-gimeracil-oteracil Potassium
PubMedID_Primary_Reference
  • 15224197
UMLS_CUI
  • C0879262
CAS_Registry
  • 154239-56-2
In_Clinical_Trial_For
  • Colorectal and Advanced Gastric Cancer Carcinoma.
ALT_DEFINITION
  • A drug that is being studied for its ability to enhance the effectiveness of fluorouracil and prevent gastrointestinal side effects caused by fluorouracil. It belongs to the family of drugs called antimetabolites.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 43548
PDQ_Closed_Trial_Search_ID
  • 43548
Legacy_Concept_Name
  • S-1
FULL_SYN
  • BMS-247616PTDCP50585
  • S-1PTNCI-GLOSSCDR0000046716
  • Tegafur, mixture with Gimeracil and Potassium OxonateSYNCI
  • S-1CNNCI
  • Tegafur-gimeracil-oteracil PotassiumPTNCI
  • TS-1CNNCI
  • BMS 247616CNNCI
DEFINITION
  • An orally bioavailable fluoropyrimidine antagonist composed of tegafur combined with two modulators of 5-flurouracil (5-FU) activity, gimeracil and potassium oxonate, in a molar ratio of 1:0.4:1. Tegafur is a prodrug of 5-fluorouracil, an antimetabolite that inhibits thymidylate synthase, DNA synthesis and cell division, and competes with uridine triphosphate, thus inhibiting RNA and protein synthesis. Gimeracil is a reversible inhibitor of dihydropyrimidine dehydrogenase (DPD), the liver enzyme responsible for rapid catabolism of 5-FU into inactive metabolites. Potassium oxonate preferentially localizes in the gut and inhibits the enzyme orotate phosphoribosyl-transferase (OPRT), thereby decreasing activation of 5-FU in the gut and activated 5-FU-related gastrointestinal toxicity.NCI
code
  • C1833
is someValuesFrom of
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